Efficacy of endoscopic pancreatic sphincterotomy preceding extracorporeal shock wave lithotripsy for pancreatolithiasis

s / Pancreatology 14 (2014) S1eS129 S25 Aims: This study was conducted to compare sedation efficiency, safety and satisfaction by endoscopist and assistants between CI and IB of propofol for deep sedation during ERCP. Patients & methods: A total of 212 patients undergone ERCP were randomly assigned to either CI of propofol (n1⁄4106, continuous group (CG)) or midazolam plus IB of propofol (n1⁄4106, intermittent group (IG)). In the CG, propofol was continuously administered via infusion pump and the doses were determined by sedation assistants. In the IG, a loading dose of 2 mg of midazolam and 0.4 mg/kg of propofol was initially injected and repeated bolus injection of 20 mg of propofol was followed. Total dose of propofol, induction/recovery time, patients’ cooperation and adverse events during the procedure were evaluated. Satisfaction scores by patients/endoscopist and difficulty scores of maintaining the sedation by assistants were graded. Results: Induction time and recovery time showed no statistically significant differences between two groups. Satisfaction score by endoscopist was significantly higher in the CG than IG (9.62 vs. 8.06, p Conclusion: Continuous infusion of propofol was more efficient to maintain the constant level of sedation and more comfortable to endoscopist and sedation assistants for deep sedation during ERCP.