Influence of the drying technique on theophylline pellets prepared by extrusion-spheronization.

Abstract Extrusion–spheronization is frequent method for pellet production and especially extrusion stage has been studied for its influence on pellet properties. However, the formation of pellet structure is not finished before drying stage. The possible influence of different drying methods and used temperatures on some properties of pellets, containing theophylline as active ingredient and Avicel® CL-611 as spheronizing agent, is the object of this paper.