Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

Isabel Kurth,Norihiro Yamaguchi,Celia Andreu-Agullo,Helen S. Tian,Subhasree Sridhar,Shugaku Takeda,Foster C. Gonsalves,Jia Min Loo,Afsar Barlas,Katia Manova-Todorova,Robert Busby,Johanna C. Bendell,James Strauss,Marwan Fakih,Autumn J. McRee,Andrew Eugene Hendifar,Lee S. Rosen,Andrea Cercek,Robert Wasserman,Michael Szarek,Scott L. Spector,Syed Ahsan Raza,Masoud Tavazoie,Sohail F. Tavazoie

Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

2021

Colorectal cancer (CRC) is a leading cause of cancer mortality. Creatine metabolism was previously shown to critically regulate colon cancer progression. We report that RGX-202, an oral small-molec...

Keywords:

Creatine
Cancer research
Colorectal cancer
Creatine transporter
Medicine
cancer mortality
therapeutic targeting
Creatine metabolism

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