Mathematical modeling of lysozyme crystal growth under thermal control field for terrestrial and space conditions

Abstract A method is described for high-quality protein crystal solution growth with the help of localized action of a thermal control field. A mathematical model has been developed and computational investigation has been performed of the processes of lysozyme crystallization from a homogeneous aqueous solution in the crystallization volume as well as crystal growth by counter-diffusion. The mathematical model describes crystal nucleation and growth depending on the local supersaturation and temperature as well as heat-and-mass exchange within the entire volume of the solution including the protein crystals.