Diagnostic value of thyroglobulin measurement in fine-needle aspiration biopsy for detecting lymph nodes metastasis in patients with papillary thyroid cancer
2013
Objective To investigate the diagnostic value of thyroglobulin measurement in fine-needle aspiration biopsy(FNA-Tg).Methods This study included 63 patients with thyroid cancer or with enlarged lymph nodes during the follow-up from Aug.2010 to Jun.2012.Ultrasound-guided fine-needle aspiration was done in the 63 patients with 79 suspicious enlarged lymph nodes.Then thyroglobulin(Tg) in FNA washout fluid and serum Tg were assayed with electrochemiluminescenceimmunoassay(ECLIA).Diagnostic sensitivity,specificity and area under the ROC curve were evaluated according to 5 predetermined threshold levels:FNA-Tg/serum-Tg > 1,mean + 2SD of node-negative patients,10 ng/ml,optimal operating point of ROC curve and 1000 ng/ml.Results The sensitivity value was 90.70%,90.70%,95.35%,90.70% and 65.12% respectively on the 5 threshold level,significantly lower than those on the threshold level of 1000 ng/ml(P <0.05).The specificity value was 97.22%,91.67%,72.22%,97.22% and 100% (P >0.05) on those threshold levels,significantly lower than those on the threshold level of 10 ng/ml (P <0.05).The area under the ROC curve was 0.940,0.912,0.838,0.940 and 0.826 respectively.There was no statistical difference(P >0.05).Conclusion Selecting FNA-Tg/serum-Tg > 1 as a positive threshold value can be a secondary diagnosis of lymph nodes metastasis in patients with papillary thyroid cancer.
Key words:
Fine-needle aspiration; Thyroglobulin; Lymphatic metastasis; Papillary thyroid cancer
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI