A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis.
2007
Interleukin-12 receptor beta-1 (IL-12Rβ1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12Rβ1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.
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