Assessment of changes in lipid profile and related enzymes in children with asthma

Purpose: To investigate the influence of the lipid profile and related parameters on the development of asthma in children aged 10 to 15 years. Methods: Peripheral blood samples were collected from a group diagnosed with asthma as well as from a healthy control group. The lipid profile parameters measured were total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), high-density lipoprotein (HDL), serum total antioxidant capacity (TAC), reduced glutathione (GSH), and malondialdehyde (MDA), and the activities of lecithin–cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP). Results: TC, TG, LDL, and VLDL levels were significantly ( p ≤ 0.05) higher in the asthma group compared with the controls, while HDL level was lower. Total TAC and GSH were lower in the asthma group, while MDA level, and LCAT and CETP activities were higher. Conclusion: There is a link between an elevated lipid profile and increased antioxidant capacity in asthmatic children.