Landscape scanning of cancer gene panels: A report from the NIH Genetic Testing Registry (GTR).

e13120Background: Genetic testing of tumors and germlines has proliferated in oncology, as gauged by ASCO’s meeting topics and the medical literature. A quantitative appraisal of orderable genetic tests over recent years can provide insight into the evolution of oncology practice. GTR (https://www.ncbi.nlm.nih.gov/gtr/) is a freely available web resource created to enable centralized access to comprehensive information about genetic tests and improve transparency. GTR panel analyses were used by AMA to help create new CPT codes and by CDC to prioritize the development of next-generation sequencing (NGS) reference materials. Methods: We compared GTR content available February 2014, 2015 and 2016 by querying the GTR database for lab and test attributes such as methods, genes, and indications. We defined a gene panel as having > 4 targets and a commonly tested gene as being in > 99 tests. Comprehensive GTR data can be downloaded in XML format using FTP or E-Utilities. Results: As of 2/1/16, GTR has 32,969 te...