Hemodynamic effects of continuous negative chest pressure ventilation in heart failure

We have previously shown improved cardiac output (t) with external continuous negative-pressure ventilation (CNPV) compared with continuous positive-pressure ventilation (CPPV) in dogs with low pressure pulmonary edema (1). The current study was done to determine if this effect was reversed in high pressure pulmonary edema.Seven supine, anesthetized dogs were fluid-loaded and treated with disopyramide (3.5 to 7.0 mg/kg) and propranolol (0.25 to 1.5 mg/kg). This produced a mean pulmonary wedge pressure (Ppaw) of 21.0 mm Hg on intermittent positive-pressure ventilation (IPPV). CPPV and CNPV were then alternated at 30-min intervals. Ventilators were matched for oxygen concentration, frequency, tidal volume (Vt), and the increment in FRC (ΔFRC) produced by a given positive (PEEP) or negative (NEEP) end-expiratory pressure. During 20 cm H2O of PEEP, t values were significantly depressed from IPPV control values (2.13 ± 0.2 versus 1.27 ± 0.2 L/min, p < 0.05) but not during CNPV with equivalent NEEP (1.66 ± 0.2 ...