Antidiabetic activity of Ethyl acetate and Ethanolic extract of Scindapsus officinalis fruit in Alloxan Induced Diabetic rats.

The climber Scindapsus officinalis 1 (Roxb.) belongs to family Araceae which is known as Anaittippilli in Tamil 2 . In the present study ethyl acetate (EAESOF) and ethanolic (EESOF) extract of Scindapsus officinalis fruit were subjected to the phytochemical investigation and evaluated for antidiabetic activity on blood glucose level, lipid profiles and on the body weight in alloxan induced diabetic rats. EAESOF & EESOF (200 mg/kg) and Glibenclamide (10mg/kg) were administered orally in alloxan (120 mg/kg, i.p.) induced diabetic rats. In this antidiabetic study, maximum reduction in blood glucose was observed in EAESOF & EESOF(160.8, 96.7 mg/dl) at the dose of 200 mg/kg on 21st day respectively. The EAESOF & EESOF showed the significant effect (p<0.005) in the various biochemical parameters like protein, triglycerides, cholesterol and total lipid levels. EAESOF & EESOF prevented further loss of body weight. EAESOF & EESOF (200 mg/kg) was found to have significant (p<0.001) blood glucose lowering effect. Preliminary Phytochemical investigation revealed the presence of alkaloids, flavonoids, saponins and tannins as the major constituents in the ethyl acetate & ethanol extract. These results suggest that EAESOF & EESOF (200 mg/kg) showed antidiabetic activity in alloxan induced diabetic rats.