Abstract 17234: Comparing the Efficacy of Primary Prevention Strategies in Doxorubicin-induced Cardiotoxicity using Echocardiography and High-Sensitivity Troponin T

Introduction: Detection of chemotherapy-induced cardiotoxicity has historically relied on clinical presentation and cardiac imaging measures. Recently, global longitudinal peak systolic strain (GLS) measures with speckle tracking echocardiography (STE) and high-sensitivity troponin T (hs-TnT) have been utilized to evaluate the development of cardiotoxicity. The increased sensitivity of these methods may allow us to differentiate the relative difference in efficacy amongst primary prevention strategies. Hypothesis: We tested the hypothesis that GLS or hs-TnT will differentiate the efficacy between dexrazoxane and continuous infusion of doxorubicin in preventing doxorubicin-induced cardiotoxicity. Methods: Twenty-three patients with newly diagnosed sarcoma were assigned to receive 72-hours doxorubicin infusion (13 patients) or doxorubicin + dexrazoxane injection (10 patients). hs-TnT was monitored before, at 24 and 72 hours of each chemotherapy cycle. All samples were assayed at the same time using hs-TnT (...