The pharmacokinetics of oral oxycodone in patients after total gastric resection

3126 Abstract. - OBJECTIVE : Oxycodone is a se - mi-synthetic opioid with a stronger analgesic ef - fect than morphine and codeine.The efficacy of this opioid in the treatment of postoperative pain has been proved in different groups of pa - tients. The drug has a favourable adverse reac - tion profile, which encourages doctors and pa - tients to use it more and more widely. The drug is also used in the patients who underwent an abdominal surgery, e.g. stomach resection. Gas - trectomy leads to pathophysiological changes within the gastrointestinal tract, which may cause changes in the drug absorption. In conse - quence this leads to a change in the pharmaco - kinetics and effect of the drug. The aim of the research was an analysis of the pharmacokinet - ics of oxycodone from prolonged release tablet in patients after total gastrectomy.