Oncologic risk factors in papillomavirus infection

Cytological screening is essential for adequate diagnosis of gynecological cancer. Moreover every effort should be made to identify such risks of cancer as viruses (HPV Herpes simplex cytomegalovirus Epstein-Barr virus etc.). When high risk HPV-16 and HPV-18 are detected diagnostic strategies should include assay of blood prolactin and prolactin/TTH ratio. Virus-related tumors and various risk groups may be studied using HPV genotyping detection of high-risk alleles of certain genes. Hence some HPV gene variants and gene polymorphism can be investigated as potential risk factors in women. (excerpt)