Hospitalizaciones y mortalidad por COVID-19 en pacientes con enfermedades inflamatorias reumáticas en Andalucía

Resumen OBJETIVO: Describir si las enfermedades inflamatorias reumaticas (EIR) se asocian con mayor riesgo de hospitalizacion y/o mortalidad por COVID-19 e identificar los factores asociados a la hospitalizacion y mortalidad en EIR y COVID-19 en diferentes Hospitales de Andalucia METODOS: Diseno: Estudio multicentrico observacional de casos y controles Pacientes: Casos: EIR y COVID-19 de diferentes centros de Andalucia Controles: pacientes sin EIR pareados por sexo, edad y PCR-COVID Protocolo: se solicito al servicio de microbiologia un listado de pacientes con PCR para COVID-19 desde 14 de marzo al 14 de abril de 2020 Se identificaron los pacientes que tuvieran EIR y luego consecutivamente un control pareado para cada caso Variables: La variable de desenlace principal fue ingreso hospitalario y mortalidad por COVID-19 Analisis estadistico: bivariante seguida de modelos de regresion logistica binaria (Vd : mortalidad/ingreso hospitalario) RESULTADOS: Se incluyeron 156 pacientes con COVID-19, 78 con EIR y 78 sin EIR Los pacientes con EIR no presentaron caracteristicas de la enfermedad COVID-19 diferentes a la poblacion general, tampoco mayor ingreso hospitalario ni mortalidad El factor asociado con mortalidad en los pacientes con EIR fue edad (OR [IC 95%], 1,1 [1,0-1,2];p=0,025), mientras que los factores asociados a ingreso hospitalario fueron edad (OR [IC 95%], 1,1 [1,1-1,2];p=0,007) e hipertension arterial (OR [IC 95%], 3,9 [1,5-6,7];p=0,003) CONCLUSION: La mortalidad y el ingreso hospitalario por COVID-19 no parecen aumentados en las EIR La edad se asocio con mortalidad en EIR y, ademas, la hipertension arterial se asocio con ingreso hospitalario ABSTRACT OBJECTIVE: To describe whether rheumatic inflammatory diseases (RID) are associated with a higher risk of hospitalization and / or mortality from COVID-19 and identify the factors associated with hospitalization and mortality in RID and COVID-19 in different Hospitals in Andalusia METHODS: Design: Multicentre observational case-control study Patients: RID and COVID-19 from different centres in Andalusia Controls: patients without RIS matched by sex, age and CRP-COVID Protocol: a list of patients with PCR for COVID-19 was requested from the microbiology service from March 14 to April 14, 2020 The patients who had RID were identified and then consecutively a paired control for each case Variables: The main outcome variable was hospital admission and mortality from COVID-19 Statistical analysis: bivariate followed by binary logistic regression models (DV: mortality / hospital admission) RESULTS: One hundred and fifty-six patients were included, 78 with RID and COVID-19 and 78 without RID with COVID-19 The patients did not present characteristics of COVID-19 disease different from the general population, nor did they present higher hospital admission or mortality The factor associated with mortality in patients with RID was advanced age (OR [95% CI], 1 1 [1 0-1 2];p = 025), while the factors associated with hospitalization were advanced age (OR [95% CI], 1 1 [1 0-1 1];p = 007) and hypertension (OR [95% CI], 3 9 [1 5-6 7] ;p = 003) CONCLUSION: Mortality and hospital admission due to COVID-19 do not seem to increase in RID Advanced age was associated with mortality in RID and, in addition, HTN was associated with hospital admission