Heteroatom‐Guided, Palladium‐Catalyzed, Site‐Selective C—H Arylation of 4H‐Chromenes: Diastereoselective Assembly of the Core Structure of Myristinin B Through Dual C—H Functionalization.

A highly site-selective, heteroatom-guided, palladium-catalyzed direct arylation of 4H-chromenes is reported. The C-H functionalization is driven not only by the substituents and structure of the substrate but also by the coupling partner being used. The diastereoselective assembly of the core structure of Myristinin B has been achieved by using a dual C-H functionalization strategy for regioselective direct arylation.