Désordres de la constellation autistique : un monde trop rapide pour un cerveau disconnecté ? 1 Autistic constellation disorders: too rapid world for disconnected brain?

In the continuation of the concepts of E-Motion mis-sight and Temporo-Spatial Processing Disorders (TSPD) of multi-sensory stimuli, we carry on our develop- mental theory of autism. We first remind that TSPDs consist in difficulties and peculiarities perceiving and integrating online the temporal and spatial characteritics of the incoming sensory events in the visual, auditory and proprioceptive modalities. Via the clinical manifestations exhibited by a baby at risk for autism, some self reports of autistic adults, and several experimental results, we show how the TSPDs might be central for the main behavioral, imitative, sensory- motor and cognitive disorders of at least some autistic per- sons. Then we present a new concept, the Multi-system Brain Disconnectivity-Dissynchrony (MBD), which repre- sents the various degrees of under- or over- functional connectivity and hypo- or hyper-synchronization between numerous brain regions, and show that MBD might consi- tute the neurophysiological basis of TSPDs. We finally pre- sent the therapeutical applications and clinical perspectives that emerge from our approach, in particular via slowing down the environmental visual and auditory signals.