Therapeutic effects of Δ9-THC and modafinil in a marmoset Parkinson model

Current therapies for Parkinson's disease (PD) like L-dopa and dopamine (DA) agonists have declined efficacy after long term use. Therefore, research towards supplementary or alternative medication is needed. The implementation in PD can be expedited by application of compounds already used in the clinic. In this study the therapeutic effects of the psychoactive compounds Δ 9 tetrahydrocannabinol (Δ 9 -THC) and modafinil were tested in the 1-methyl-1,2,3,6-tetrahydro