Quetiapine in post-transplant acute mania/bipolar disorder NOS.

There is no medication specifically approved for the treatment of bipolar disorder not otherwise specified (BD-NOS), substance-induced mood disorders and mood disorders due to a general medical condition. We report the case of a man whose post-transplant BD-NOS was treated successfully with quetiapine. Mr G, a 58-year-old man with cystic fibrosis and no history of psychiatric disorders, as documented by a pre-transplant SCID evaluation, received lung transplantation in December 2004. The patient underwent the post-transplant course with no medical or psychiatric complications until 6 wk after the transplant, when he developed decreased need for sleep, euphoria, irritability, grandiosity, pressured speech, flights of ideas, increased sexual drive, mystical and grandiose delusions. His symptoms led him to a poor adherence to the post-transplant immunosuppressant treatment and to other …