Lactate signalling regulates fungal β-glucan masking and immune evasion

Elizabeth R. Ballou,Gabriela M. Avelar,Delma S. Childers,Joanna Mackie,Judith M. Bain,Jeanette Wagener,Stavroula Kastora,Mirela D. Panea,Sarah E Hardison,Louise A. Walker,Lars P. Erwig,Carol A. Munro,Neil A. R. Gow,Gordon D. Brown,Donna M. MacCallum,Alistair J. P. Brown

Lactate signalling regulates fungal β-glucan masking and immune evasion

2017

Elizabeth R. Ballou
Gabriela M. Avelar
Delma S. Childers
Joanna Mackie
Judith M. Bain
Jeanette Wagener
Stavroula Kastora
Mirela D. Panea
Sarah E Hardison
Louise A. Walker
Lars P. Erwig
Carol A. Munro
Neil A. R. Gow
Gordon D. Brown
Donna M. MacCallum
Alistair J. P. Brown

In response to lactate exposure, Candida albicans induces masking of β-glucan, a key PAMP, via a signalling pathway involving the Gpr1 receptor and Crz1 transcription factor.

Keywords:

Hedgehog signaling pathway
GPR1
Transcription factor
Immune system
Glucan
Candida albicans
Molecular biology
Medicine
Receptor
Innate immune system
Antigen
Corpus albicans
Cell biology

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