Influence of pH on the Spherical Shape and Particle Size of the Freeze Drying Assisted Sol-gel Derived Silica Nano-Particles (SNPs)

The spherical silica nanoparticles (SNPs) are synthesized by freeze drying assisted sol gel method and the effect of pH on morphology and particle size is studied. The Tetraorthosilicate (TEOS) was used as silane source and Polyethylene Glycol 6000(PEG 6000) was used as capping agent for controlling the shape of the particles. The synthesized (SNPs) were analyzed using Zeta size Analyzer which confirmed the particle size in the range of 24-1090 nm at different pH values of the solution. The  Fourier Transform Infrared (FTIR) Spectroscopy was used to characterize the functional moieties present in the synthesized material which confirmed the presence of functional vibration groups corresponding to silica particles which are mainly Si-O-Si asymmetric stretching (1034-1120 cm -1 ), Si-O rocking (443-487cm -1 ) and Si-O bending (760-800 cm -1 ) , X-Ray Diffraction (XRD) analysis of the synthesized nano silica particles confirmed the amorphous nature and  Scanning Electron Microscope (SEM) was used to study the morphology of the synthesized (SNPs) which confirmed the spherical shape of the (SNPs) and it was found that shape tend to deform on increase of the pH of the solution . for treatment of chronic wound. Chronic wounds present a challenge that is costly in terms of quality of life to the patient. Siddha system of medicine possesses lots of medicines to treat chronic wounds effectively. Pachchai Servai is one of the herbo-mineral external medicine has been using for treatment of chronic wound. Here, an attempt has been made to review the explored ethno pharmacological activities of the ingredients of Pachchai Servai to strengthen the scientific facts favouring this formulation.