Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus.

Bruce David Roth,Daniel F. Ortwine,Milton Louis Hoefle,Charlotte D. Stratton,Drago R. Sliskovic,Michael William Wilson,Roger S. Newton

Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus.

1990

Bruce David Roth
Daniel F. Ortwine
Milton Louis Hoefle
Charlotte D. Stratton
Drago R. Sliskovic
Michael William Wilson
Roger S. Newton

Synthese des composes du titre a partir des dicetones-1,4 appropriees. Mesure in vitro de leur capacite d'inhibiteur vis-a-vis de l'HMG-CoA reductase. Le derive (fluoro-4 phenyl)-5 isopropyl-2 est le plus actif

Keywords:

Cofactor
HMG-CoA reductase
Pyrrole
Reductase
Biochemistry
Molecular model
Lactone
Stereochemistry
Organic chemistry
Enzyme inhibitor
In vitro
Chemistry
Pharmacophore
Ene reaction
Side chain

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