P274 Comparison of the initiation of copd treatment with licensed fdc ics/laba treatments in terms of disease control and cost effectiveness

Several fixed-dose combination inhaled corticosteroid (FDC ICS/LABA) inhalers are licensed for chronic obstructive pulmonary disease (COPD) in the UK. This study compares effectiveness of Fostair 100/6 (BDP/FOR) metered dose inhalers (MDI) against other licensed FDC ICS/LABAs, namely; Seretide Accuhaler 500 (FP/SAL) dry powder inhaler (DPI) and Symbicort Turbohaler 200/6 and 400/24 DPI (BUD/FOR) in a patient group with recent exacerbations and poor lung function. A historical cohort study using data extracted from the Optimum Patient Care Research Database. Patients with diagnostic read codes for COPD, smoking history, age ≥35 years, postdose FEV 1 percent predicted 1 percent predicted and exacerbations. Mean total costs consisting of medication/resource costs were compared between treatment arms after adjusting for confounders. Out of the patients prescribed BDP/FOR (n=537) and 537 FP/SAL (n=537), the median age was 70 and 69 respectively and 41.7% were current smokers. In the BDP/FOR (n=540) and BUD/FOR (n=540) comparison, the median age was 70 and 69 respectively, and 42% were current smokers. The risk of ≥1 exacerbation in BDP/FOR group was non-inferior during the year following the initiation of ICS/LABA compared to FP/SAL (OR 0.89, 95% CI: 0.67–1.19) or BUD/FOR (OR 0.79, 95% CI: 0.58–1.08). Cost was significantly lower for BDP/FOR versus FP/SAL (adjusted mean £730.0 versus £850.1 respectively, p