Procedure for obtaining multi-functionalized materials
2011
Process for obtaining multi-functionalized materials # The present invention describes a process for producing multifunctional materials comprising the steps of: a) chemical activation of functional groups present in a micro or nanoparticulate based material;. b) nucleophilic substitution reaction between at least one amino, carboxyl or thiol terminus of a PNA strand or DNA type and at least one activated functional group of the base material obtained in step (a); c) conjugation to a biomolecule by chemical activation of functional groups of a chain of PNA / DNA type B, complementary to the PNA / DNA chain type ,; d) hybridization of PNA / DNA type A chains, which are attached to the base material in step b) and chains PNA / DNA type B having bound biomolecules, according to step c) by molecular recognition PNA-PNA or PNA -DNA.
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