Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats

Xiaohua Shen,Bo Hu,Guangtao Xu,Fengjuan Chen,Ruifen Ma,Nenghua Zhang,Jie Liu,Xiaoqin Ma,Jia Zhu,Yuhong Wu,Ruilin Shen

Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats

2017

Xiaohua Shen
Bo Hu
Guangtao Xu
Fengjuan Chen
Ruifen Ma
Nenghua Zhang
Jie Liu
Xiaoqin Ma
Jia Zhu
Yuhong Wu
Ruilin Shen

Background/Aims: Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective eff

Keywords:

Internal medicine
Endocrinology
Diabetes mellitus
GSK-3
Renal ischemia
NF-κB
Reperfusion injury
Medicine
Oxidative stress
Creatinine
Malondialdehyde
Renal function
Kidney
Superoxide dismutase
Blood urea nitrogen
Nitric oxide

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