A propensity-matched analysis comparing hepatic recurrence after curative gastrectomy followed by adjuvant HIPEC to surgery alone for advanced gastric cancer.

4056Background: Prevention of recurrence after curative (R0) surgery is one of the most important subjects to be resolved for gastrointestinal (GI) cancers. We have previously shown that hyperthermic intraperitoneal chemotherapy (HIPEC) following R0 gastrectomy is effective for preventing peritoneal recurrence. However, little is known about the preventive effect of HIPEC for GI cancers on hepatic recurrence. The aim of this study was to compare hepatic or peritoneal recurrence-free survival between patients with or without adjuvant HIPEC after R0 gastrectomy for an advanced gastric cancer (GC). Methods: Patients with advanced GC who underwent gastrectomy with a curative intent in the Shiga University of Medical Science hospital between 1998 and 2012 were included in this single center, retrospective, propensity score-matched cohort study. Cox proportional hazards regression models were used to evaluate the association between adjuvant HIPEC and hepatic or peritoneal recurrence-free survival. The Kaplan-M...