Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives

A range of N -benzylic and N -phenethylic ephedrine derivatives were prepared in a one-pot procedure starting from the two enantiomers of ephedrine using the Potier reagent, and a polyfunctional aryl- or benzylic organozinc halide. The biological activity in indatraline MS Binding Assays addressing hDAT, hNET and hSERT was determined and discussed.