Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives
2017
A range of N -benzylic and N -phenethylic ephedrine derivatives were prepared in a one-pot procedure starting from the two enantiomers of ephedrine using the Potier reagent, and a polyfunctional aryl- or benzylic organozinc halide. The biological activity in indatraline MS Binding Assays addressing hDAT, hNET and hSERT was determined and discussed.
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