Influence of induced immunosupression on inflammation and lungs remodeling on the COPD model

Goal: to evaluate the effect of induced immunosuppression on the nature and speed of structural-functional disturbances formation in the lungs on the COPD model. Methods: The COPD model was created in Wistar rats by exposure with nitrogen dioxide (NO2, 15-19 ppm): three 30-minute exposures per day with 30 min intervals for 60 days. To create immunosuppression, an alkylating agent cyclophosphamide was injected intraperitoneally twice, the control group got 0.9% NaCl. BAL fluid cytogram was determined. The presence of IL-8, IL-17, neutrophil elastase (NE), sIgA, SP-D in BAL fluid was measured by ELISA method. Histological preparations were stained with HE TNFα-up to 35.48±2.08 vs 25.45±1.33 pg/ml in control, p Conclusion: When aggressive pollutants damaging the respiratory epithelium are exposed, the initial immune dysfunction maycontribute to the formation of a pro-inflammatory environment and the phenotype of premature lungs aging, predisposing to the development of chronic obstructive pulmonary pathology.