The role of tissue transglutaminase in cell-matrix interactions

1. Abstract2. Introduction3. Cell surface tTG and its non-enzymatic function in cell-matrix adhesion3.1. tTG-FN interaction3.2. Association of tTG with integrins3.3. Other molecular interactions of tTG on the cell surface3.4. Regulation of cell surface tTG4. Cell surface tTG and FN matrix assembly5. Involvement of surface tTG in cell migration6. Modulation of integrin-mediated signaling by surface tTG7. Protein cross-linking activity of tTG and its role in cell-matrix interactions and matrix stability8. Contribution of the GTPase function of tTG to cell-matrix interactions9. Summary and future directions10. Acknowledgements11. References