Effect of a high serum uric acid diet and injections of urate crystals on adjuvant arthritis in the rat

: The difference between gout and rheumatoid arthritis was reproduced experimentally in the rat by combining adjuvant arthritis with an oxonate uric acid raising diet and injections of crystals of sodium urate. The factorial experiment using 3 factors confirms the inhibition or arthritis by a uric acid raising diet and shows that the injections of crystals, which preceed the injection of Freund's adjuvant, increase the arthritic lesions in normo-uricemic rats and reduces them slightly in hyperuricemic rats. This effect of the injection of crystals increases gradually with time.