Development of a Practical Sequence for Difluoromethylation of 2‐Bromopyridines via Copper‐Mediated Reductive Coupling and Decarboxylation

A practical process was developed for the synthesis of 2-difluoromethylpyridines via a Cu-mediated Reductive Coupling-Hydrolysis-Decarboxylation sequence. The process employed 2-bromopyridines with a variety of functional groups on the pyridine as substrates and used readily available and inexpensive starting materials. For operational safety DMSO shall not be considered as solvent and the use of DMF is recommended.