Effect of glucagon on glucose output from bivascularly perfused rat liver.

Glucose output was investigated in bivascularly perfused rat liver. Flow rate was 1 ml/min/g from hepatic artery and 2 ml/min/g from portal vein. Basal glucose output from bivascularly perfuse liver was significantly higher than that from usual monovascularly perfused liver. However, glucagon-induced increment in glucose output from bivascularly perfused liver was not significantly different from that of monovascularly perfused liver