Internal cardiac defibrillation: Histopathology and temporal stability of defibrillation energy requirements

The automatic implantable cardioverter/defibrillator is tested intraoperatively to ensure effectiveness by performing a number of induced fribrillation-defibrillation trials. The temporal stability of defibrillation energy requirements and the histopathologic effects of multiple defibrillating shocks were studied in 12 dogs chronically instrumented with an internal spring-patch lead system identical to that used in humans. Dogs were studied on days 1, 11, 18, 25 and 32. Data were analyzed by logistic regression and the energy required for 50% (E 50 ) and 80% (E 80 ) success was compared. On day 32 the dogs were killed and the heart was removed for gross and microscopic pathologic examination. There was a significant decrease in energy requirements from day 1 to day 11, as the E 50 decreased from 6.9 ± 4.5 to 4.9 ± 2.5 J (p 80 decreased from 8.5 ± 5.2 to 6.1 ± 3.4 J (p Therefore, the energy requirements for successful defibrillation decrease during the first 11 days after testing at implantation, and then remain stable. Also, multiple, closely spaced defibrillating shocks applied through the spring-patch electrode system do not cause myocardial damage or changes other than those associated with the implantation.