Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
2016
In this Letter, we published the crystal structure of a heterodimer of the human (h)CEACAM1 IgV domain and hTIM-3 IgV domain (Protein Data Bank (PDB) accession 4QYC). Since publication, E. Sundberg and S. Almo have questioned our model, and stated that they had obtained better results refining a hCEACAM1–hCEACAM1 homodimer model against our diffracted amplitudes. We confirm that a homodimer model indeed fits our crystallographic data better, as judged by most statistical measures (see Supplementary Table 1). We have therefore withdrawn the deposited heterodimer model (PDB code 4QYC) from the PDB, and replaced it with a more accurate homodimer model (PDB code 5DZL). We thank E. Sundberg and S. Almo for bringing this to our attention, and apologize for any confusion the original structure may have caused.
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