Dihydronaphthalenones from endophytic fungus Fusarium sp. BCC14842

Abstract Eleven new dihydronaphthalenones 1 – 11 , together with five known compounds; 5-hydroxydihydrofusarubin C ( 12 ), javanicin, bostrycoidin, anhydrofusarubin, and 3- O -methylfusarubin, were isolated from the endophytic fungus Fusarium sp. BCC14842 . Structures were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. Javanicin, 3- O -methylfusarubin, compounds 3 and 7 exhibited antimycobacterial and cytotoxic activities. Javanicin also displayed antifungal activity with IC 50 of 6.16 μg/mL, while compounds 2 , 4 , 5 , 8 , and 12 showed only cytotoxic activity.