Echo decorrelation imaging for quantification of tissue structural changes during ultrasound ablation

2014 
Echo decorrelation imaging is a pulse-echo method that maps millisecond-scale changes in backscattered ultrasound signals, potentially providing real-time feedback during thermal ablation treatments. Decorrelation between echo signals from sequential image frames is spatially mapped and temporally averaged, resulting in images of cumulative, heat-induced tissue changes. Theoretical analysis indicates that the mapped echo decorrelation parameter is equivalent to a spatial decoherence spectrum of the tissue reflectivity, and also provides a method to compensate decorrelation artifacts caused by tissue motion and electronic noise. Results are presented from experiments employing 64-element linear arrays that perform bulk thermal ablation, focal ablation, and pulse-echo imaging using the same piezoelectric elements, ensuring co-registration of ablation and image planes. Decorrelation maps are shown to correlate with ablated tissue histology, including vital staining to map heat-induced cell death, for both ex...
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