Trigger and Signal Mechanisms and the End Effector of the Cardioprotective Effect of Remote Postconditioning of the Heart

High molecular weight peptide(s) operate as the trigger for remote postconditioning (RPC) of the heart. Nitric oxide and adenosine function as mediators between peptide and intracellular structures. The autonomic nervous system does not have a role in RPC. The signal mechanism of RPC involves protein kinase C, PI3 kinase, Akt kinase, and aldehyde dehydrogenase. The hypothetical end effector of RPC is the BKCa channel