Effect of air bubbles localization and migration after embryo transfer on assisted reproductive technology outcome

Objective To evaluate the effect of embryo flash position and movement of the air bubbles at 1 and 60 minutes after ET on clinical pregnancy rates (PRs). Design Prospective clinical trial. Setting University fertility clinic. Patient(s) A total of 230 fresh ultrasound-guided ETs performed by a single physician (C.F.) at the IVF center of Yeditepe University Hospital between September 2016 and February 2017 were included. Intervention(s) Transabdominal ultrasonographic guidance at ET. Main Outcome Measure(s) Clinical PRs. Result(s) There was no significant difference in terms of clinical PRs between women with embryo flash located >15 mm and P =.6 and P =.7, respectively). The PRs in women with embryo flash located 15 mm from the fundus were 47% and 60%, respectively ( P =.6). The clinical intrauterine PRs were 69.5%, 38.5%, and 19.1% in fundal, static, and cervical, respectively. The highest PR was in fundal when compared with others ( P Conclusion(s) We concluded that clinical PR appears to be associated with the embryo flash movement/migration at 60 minutes after ET and embryo flash movement toward the fundus is associated with higher clinical PRs. Further well-designed randomized controlled trials are required to optimize ET technique in the future.