Synthesis and Anti-Microbial Activity of Some Novel Mannich Base Aryl Imidazole Derivatives

Mannich base aryl imidazole derivatives were synthesized by condensing Primary aromatic amines and Aryl aldehydes in presence of glacial acetic acid to give respective Schiffs bases, which on further treatment with Ammonium acetate and Isatin in presence of glacial acetic acid to produce aryl imidazoles followed by stirring with formaldehyde and primary amines for 1 hour in presence of ethanol to yield the corresponding Mannich bases. The purity of the synthesized compounds were checked by TLC and characterized by FT-IR, Mass spectroscopy. All the synthesized compounds were evaluated for the Anti-bacterial and Anti-fungal activity. The compounds 1a, 1b, 1c, 1e, 2a showed good antibacterial activity against Staphylococcus aureus and E.coli compared to standard Ciprofloxacin. The compounds 1a, 1c, 2a showed good antifungal activity against Candida albican compared to standard Amphotericin B.