The role of lipid peroxidation in pathogenesis of hepatic enzymatic dysfunction during peritoneal intoxication

: We have investigated the role of lipid per oxidation in pathogenesis of hepatic enzymatic dysfunction during peritoneal intoxication. The investigations were carried out on 36 albino rats. I group were included intact animals, II group were included animals that peritoneal exudates reached with products of lipid per oxidation were injected to abdominal cavity and III group were included reached with animals that superoxiddismutase together with products of lipid per oxidation were injected to abdominal cavity. In all group of animals the concentration of AST, ALT, LDH, alkaline phosphates, GGT enzymes were studied and the results were compared. It was revealed that after injection peritoneal exudates to abdominal cavity, the concentration of AST is decreased and the other (ALT, LDH, alkaline phosphates, GGT) concentration are increased. In further days the blood concentration of all enzymes reached to maximal level. Additionally the injection of superoxiddismutase solution significantly decreases the concentration of these enzymes. It confirms the role of superoxiddismutase in prevention of poliorgan incipiency developing in peritonitis, as well ass in correction of hepatic dysfunction.