Strategies of Keratinocytes and Fibroblasts in Wound Closure Observed in an In Vitro Model

One of the most important functions of the integument is to maintain internal homeostasis and protect the organism from the entry of pathogens. So it is essential for any organism to repair this basic structure after an injury. Experimental investigations on wound closure are rendered difficult by technical and structural problems related to the complex microenvironment of a healing wound. Various models have been established; these reduce the complexity but consider only a few of the aspects in wound healing, for example, stripping of epidermis (e.g., Christophers 1973), suction-induced subepidermal blisters (Krawczyk 1971, 1973), or the rabbit ear chamber (Clark and Clark 1953).