Facile synthesis of 3D stone-like copper tellurate (Cu3TeO6) as a new platform for anti-inflammatory drug ibuprofen sensor in human blood serum and urine samples

Abstract Designing effectual electrocatalyst is one of the key goals of drug analysis. The severity of the dose and duration of treatment should be monitored regularly for active drug concentration in diluted human urine and blood serum samples. Herein, the development of an electrochemical sensor for the determination of ibuprofen (IBU), an anti-inflammatory agent, from human body fluids has been examined. For this purpose, facile wet-chemical synthesis of 3D stone-like copper tellurate (Cu3TeO6) as an effective electrocatalyst is reported. The synthesized Cu3TeO6 was characterized by different techniques. The Cu3TeO6/glassy carbon electrode (GCE) reveals notable electrocatalytic performance on the oxidation of IBU with the enhanced oxidation response and decreased overpotential than bare GCE owing to surface defects of metal oxides, large electroactive surface area, and fast electron transfer. Under the optimized conditions for the electrochemical determination of IBU, the dynamic detection range of 0.02-5 µM and 9-246 µM, and with a low detection limit of 0.017 µM at Cu3TeO6/GCE, respectively. The designed sensor also highlights good selectivity, high sensitivity, and exhibited long-term storage stability. The detection of IBU in human urine and blood serum samples with satisfactory recovery results (96-98.6%).