Biochemical markers of bone resorption and formation in geriatric patients with ischemic heart disease and osteoporosis

One hundred and seventy-eight patients aged 60-95 years who had ischemic heart disease (IHD) and osteoporosis (OP) were examined. The serum levels of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, apoA- and apoB-lipoproteins, calcium, phosphorus, alkaline phosphatase, etc. were measured on a Vitalab Flexor E. biochemical analyzer. Bone metabolic markers, such as parathyroid hormone (PTH), osteocalcin (OC), calcitonin (CT), as well as C-terminal telopeptides (CTTP) resulting from collagen type I (in serum and urine) were determined on a Stat Fax photometer. There was a high direct correlation between the serum levels of OC, CTTP and those of calcium and an inverse correlation between the serum concentrations of alkaline phosphatase and PTH and those of calcium in the groups of geriatric patients with IHD and OP. The plots of the function approximating the relationship of the levels of total protein, total and ionized calcium, creatinine, and alkaline phosphatase to age could predict a adaptation potential reduction in these patient groups.