ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

Liling Wan,Hong Wen,Yuanyuan Li,Jie Lyu,Yuanxin Xi,Takayuki Hoshii,Julia K. Joseph,Xiaolu Wang,Yong-Hwee Eddie Loh,Michael A. Erb,Amanda Souza,James E. Bradner,Li Shen,Wei Li,Haitao Li,C. David Allis,Scott A. Armstrong,Xiaobing Shi

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

2017

Liling Wan
Hong Wen
Yuanyuan Li
Jie Lyu
Yuanxin Xi
Takayuki Hoshii
Julia K. Joseph
Xiaolu Wang
Yong-Hwee Eddie Loh
Michael A. Erb
Amanda Souza
James E. Bradner
Li Shen
Wei Li
Haitao Li
C. David Allis
Scott A. Armstrong
Xiaobing Shi

The chromatin-reader protein ENL regulates oncogenic programs in acute myeloid leukaemia by binding via its YEATS domain to acetylated histones on the promoters of actively transcribed genes and recruiting the transcriptional machinery.

Keywords:

Acetylation
Gene expression
Chromatin
Cancer research
Gene
Histone
Transcription (biology)
Protein ENL
Biology
Promoter
Epigenetic therapy
Epigenetics
Bromodomain

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