The status of hemostasis in patients undergoing surgery with artificial circulation

: Hemostasis has been assessed in 200 patients during and after cardiopulmonary bypass surgery depending on different protamine sulphate (PS) doses injected for heparin neutralization. It has been demonstrated that the use of 1:1 PS to heparin ratio leads to adequate heparin neutralization and does not cause the appearance of residual heparin in the blood. PS administration at a dose not exceeding that of heparin was accompanied by an intraoperative decrease in platelet count and its more rapid recovery in the early postoperative period.