Computational Modelling of the Role of Atrial Fibrillation on Cerebral Blood Perfusion

Atrial fibrillation is a prevalent cardiac arrhythmia, and may reduce cerebral blood perfusion augmenting the risk of dementia. It is thought that geometric variations in the cerebral arterial structure called the Circle of Willis play an important role influencing cerebral perfusion. The objective of this work is to use computational modelling to investigate the role of variations in cerebral vascular structure on cerebral blood flow dynamics during atrial fibrillation.