Development of a shape‐controlled H 2 S delivery system using epoxide‐functional nanoparticles
2019
Hydrogen sulfide (H S), an endogenous modulator of signaling processes, has potential as a therapeutic drug or in combination drug therapies. Due to its broad biological impacts and malodorous nature, there is considerable interest in vehicles capable of delivering H S in a controlled manner. Herein, we report postpolymerization modification of polymers incorporating glycidyl methacrylate (GMA) units to form thiol-triggered macromolecular H S donors. By combining this approach with polymerization-induced self-assembly, this methodology allows the facile preparation of polymeric nanoparticulate donors with either spherical or worm-like morphology. The thiol-reactive epoxide functional groups in poly(GMA) were chemically transformed into acyl-protected perthiol groups using a three-step procedure throughout which both morphologies remained intact. The H S releasing properties were subsequently studied, with both spherical and worm-like nanoparticulate donors shown to successfully release H S in the presence of the model thiol, l-cysteine. In addition, the donor polymers were shown to effectively increase H S inside cells, upon exposure to biologically relevant endogenous thiol levels.
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