Сигнальный путь р-катенина и устойчивость клеток рака молочной железы к гипоксическим условиям

We have previously shown that Snail, a regulator of epithelial-mesenchymal transition, is activated in the hypoxia-resistant breast cancer cell line HBL-100. The purpose of this study was to evaluate the role of β-catenin signaling pathway in the maintenance of breast cancer cells’ tolerance to hypoxia. The breast cancer cell lines MCF-7 andHBL-100 were used in this study; HBL-100 cells were characterized by increased resistance to hypoxia. We have demonstrated that the transcription factor β-catenin is activated in hypoxic conditions and the β-catenin activity is supported by Snail, a regulator of epithelial-mesenchymal transition. The activated β-catenin regulates the expression of genes of the cell response to hypoxia and thus, it maintains the growth of breast cancer in the reduced oxygen conditions. The coordinated activation of Snail/β-catenin/HIF-1α proteins in cell may be considered as an important factor of tumor resistance to hypoxia.