nThe Synthesis of Perfluoroalkylated Indolizines via Tandem Cyclization/Aromatization
2021
Abstract The incorporation of a perfluoroalkyl group into heterocycles has received increasing attention. Herein we describe the synthesis of perfluoroalkylated indolizines via a tandem cyclization/aromatization process under mild conditions. In contrast to previous synthetic methods, which are usually used to construct the pyrrole motif rather than the pyridine moiety in indolizines, our protocol relies on the formation of the pyridine rings.
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