Polymorphous adenocarcinoma of the sublingual gland: A case report and literature review

Abstract Many types of malignant salivary gland tumors (SGTs) have been identified thus far, despite the rarity of these tumors. Furthermore, salivary glands comprise three paired major glands and numerous minor glands that are widely distributed in the upper aerodigestive tract region. Because of this arrangement, tumor management is complicated and cumbersome. Here, we describe polymorphous adenocarcinoma (PAC) in the sublingual gland in an 81-year-old woman with a congenital cardiac anomaly (dextrocardia). We observed a new relationship in PAC between beta-catenin and AHI-1. Further studies may provide beneficial information for PAC to establish a detection protocol or method for tumor treatment. We suggest that basic information regarding cases of PAC should be reported.