[Clinical studies on changes in serum transaminase, lactate dehydrogenase, total bilirubin and alkaline phosphatase levels after hepatectomy with and without the hemihepatic vascular occlusion technique].

Abstract Changes of serum glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH), total-bilirubin (T-Bil) and alkaline-phosphatase (AL-P) before operation and for one week of the postoperative period were studied in 45 patients (32 cirrhotic, 13 non-cirrhotic patients) who underwent hepatectomy with the hemihepatic vascular occlusion technique, and compared with 108 patients (42 cirrhotic, 66 non-cirrhotic patients) without it. The blood loss during hepatectomy with hemihepatic vascular occlusion markedly decreased 1500 ml on the average, compared with non-occluded patients. Serum GPT, GOT and LDH level elevated in several postoperative days, however, there was no difference between both groups. Serum total bilirubin level of patients without hemihepatic vascular occlusion elevated more than those with it. This difference was statistically significant. This tendency was more evident in the patients with cirrhosis. Serum AL-P level of patients without hemihepatic vascular occlusion decreased statistically less than those with it. This tendency was more prominent in patients with cirrhosis. With these results, there was no evidence of augmenting the postoperative liver damage by hemihepatic vascular occlusion, even in the patient with cirrhosis. Moreover, the elevation of postoperative serum total bilirubin level was suppressed by hemihepatic vascular occlusion because of the minimum blood loss and minimum blood transfusion.